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However, this method of entry means it can bypass the liver (unlike c-17 alpha alkylated steroids), thus entering the bloodstream immediatelyand not needing a long-term blood transfusion as an alternative to steroids. This is especially useful for patients who cannot tolerate steroids and are particularly prone to the development of liver disease.In order to maintain the effects and to avoid the need for a lifelong blood transfusion, ALKS patients begin taking DHT shortly after initiation of the treatment and continue to do so throughout the drug's clinical development. The purpose of DHT is to produce the following effects:DHT increases the conversion of LH to FSH in the hypothalamus and stimulates the production of androgens in the testes, adrenal glands, liver, and skeletal muscle to improve body androgen levels and maintain bone health.1,3While DHT also affects the prostate gland, this is not significant in comparison to a similar drug, the GnRH analog of DHT, which increases DHT effects for a single 24 h period. This is a more direct effect of DHT than the other effects on the body.DHT also induces an increase in the production of T and DHT itself also plays a role in the conversion of T into DHT, increasing the levels of progesterone in the body (but not in males).4,5With the above effects as well as other important effects, DHT is one of the most useful of the long-acting androgen replacement regimens for the development of female pattern hair loss.The use of DHT for the treatment of female pattern hair loss is not new. The use of DHT for treatment of female pattern hair loss has been documented by several studies since 1950.1,6 However, in those studies it was difficult to establish a link between DHT and female pattern hair loss.7-11 This was partly due to the fact that it was so early in drug development and partly due to the very limited evidence available; only two cases of clinical female pattern hair loss were recorded in the first period studies in which large numbers of subjects were examined.10,11 The use of DHT in the early 1950s may thus have been a response to the limitations of available data, as a study in Germany, reported that female-pattern hair loss patients receiving DHT had hair as normal as those treated with a placebo.11With the advent of newer methods of studying androgen replacement, androgen receptor polymorphisms in the female body, as well as in the human body more as a whole, a number of studies now support the relationship between female patternSimilar articles: